Abstract

Objective To investigate the correlation between cytomegalovirus (CMV) infection and graft-versus-host disease (GVHD) occurrence after allogeneic hematopoietic stem-cell transplantation (HSCT).Methods Sixty-three patients received allogeneic HSCT from Mar.1998 to Mar.2001.CMV infection and classification were tested by using polymerase chain reaction (PCR) after transplantation.The GVHD occurrence was statistically analyzed.Results 82.5％ (33/40) and 47.8％ (11/23) of patients manifested GVHD in CMV-infected and CMV-uninfected ones,which showed significant difference (P＜0.01).58.8％ (10/17),40％ (2/5),and 66.7％ (4/6) of patients manifested grade Ⅲ-Ⅳ GVHD in gB-1,gB-2,and gB-3-infected ones,respectively,which showed no significant difference (P＞ 0.05).The inhibition of haematopoietic reconstitution was observed in 27.5％ (11/40) of CMV-infected patients,which was about twice higher than in CMV-uninfected patients (13％,3/23).Conclusion CMV infection increases the risk of GVHD,but does not significantly inhibit haematopoietic reconstitution after transplantation. Key words: Cytomegavirus; Graft versus host disease; Haematopoietic reconstitution; Hematogenic stem cell transplantation; Hematogenic stem cell transplantation

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