A clinical study of the standard application of atropine for treatment of organophosphate poisoning

Abstract

Objective To study the best timing and dosage of detoxification application for acute organophosphorus pesticide poisoning for the improvement of cure rate. Methods One thousand one hundred and ninety-two cases of acute organophosphorus pesticide poisoning, treated in our hospital, were included and randomly divided into two groups. For the 560 cases in the experimental group, application of atropine was withdrawn when poisoning symptoms were observed to disappear rapidly. When mild symptoms appeared, atropine was applied again. Pyraloxime methylchloride was used for only 1-2 days. Six hundred and thirty-two cases in the control group were treated with traditional methods until atropinization and then lasted for several days, and gradually reduced until withdrawal. Information collected included application time, application dose, length of stay and adverse reaction of pyraloxime methylchloride and atropine. Two sets of data were analyzed statistically. Results Uretention, irritability, respiratory failure and other adverse reactions did not occur in the experimental group. Application time and total dose of the detoxification drug was also significantly less than the control group. Most patients could no longer be applied with detoxification drug after 24 hours and no rebound occurred after observation. Conclusions The application of new methods in the acute organophosphorus pesticide poisoning treatment can significantly improve the cure rate, shorten hospital stay and reduce adverse reactions that are caused by application of atropine and pyraloxime methylchloride excessively. Key words: Acute organophosphorus pesticide poisoning; Atropinization; Detoxification drug; Pyraloxime methylchloride; Atropine