Abstract
We performed total parenteral nutrition (TPN) with TA-3712X, an amino acid injection of a newly designed, branched chain amino acid-enriched composition, on fourteen patients (Group T) who underwent gastroenterological surgery, and studied its effects on protein metabolism in comparison with five similar post-operative patients (Group P) who received TPN with a commercially available amino acid preparation, Proteamin 12X. Post-operative nitrogen balance in Group T became positive after as few as three days, a significant improvement over Group P. Although there were no significant differences in the values of serum total protein and albumin between the two groups, Group T showed higher levels (but without statistical significance) of the rapid turnover proteins prealbumin and retinol-binding protein than those in Group P on the seventh day and thereafter. The level of transferrin in Group T was significantly higher than in Group P on the seventh day. Urinary excretion of 3-methylhistidine tended to decrease in both groups after the initiation of TPN. Thus, the use of TA-3712X after operation appears to be beneficial for efficient protein metabolism through its inhibitory effects on muscular protein catabolism as well as its stimulating effects on protein analbolism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The journal of the Japanese Practical Surgeon Society
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
