Abstract
BackgroundPathological levels of blood lipids could be one of the causes of sudden sensorineural hearing loss (SSNHL). The objective of this manuscript is therefore to evaluate the relationship between blood lipid content and sudden sensorineural hearing loss (SSNHL).MethodsThe correlation between serum lipid parameters, including total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo AI), apolipoprotein B (apo B), and lipoprotein A (Lp(a)), and the onset of SSNHL was analyzed from a data set of 250 patients and an age, gender and weight matched control group of 250 subjects.ResultsThe result of single factor logistic regression shows that TC (p<0.01), LDL-C (p<0.01), and apo B (p=0.03) of SSNHL group were significantly higher than those of the control group. The odds ratio of TC, LDL, and apo B are higher than 1, while the confidence intervals of the odds rations do not include 1. No significant difference was found with the prevalence of hypertension (P=0.818), diabetes (P=0.869) and smoking habits (P=0.653) between SSNHL group and control group.ConclusionTotal cholesterol, low density lipoprotein cholesterol and apolipoprotein B concentrations may be important factors in the pathogenesis of sudden sensorineural hearing loss, and should be assessed during the investigation of patients with this condition.
Highlights
Pathological levels of blood lipids could be one of the causes of sudden sensorineural hearing loss (SSNHL)
Dyslipidemia is one of the most significant cardiovascular risk factors [5], which is defined as a cardiovascular risk factor in the Chinese population [6], and evidence has shown that there is relationship between SSNHL and dyslipidemia [7,8,9]
No significant difference was found with the prevalence of hypertension (P=0.818), diabetes (P=0.869) and smoking habits (P=0.653) between SSNHL group and control group
Summary
Pathological levels of blood lipids could be one of the causes of sudden sensorineural hearing loss (SSNHL). The objective of this manuscript is to evaluate the relationship between blood lipid content and sudden sensorineural hearing loss (SSNHL). Prevalence rates have been reported as being from 5–20 per 100,000 people in the United States, but this is likely to be an underestimate, since many who recover quickly never seek medical attention [2]. The prevalence in Asia has not been found significantly different, with an estimate of 13 per 100,000 based on a survey of Japanese hospitals [3]. This study, a retrospective study into the serum lipid data of 250 SSNHL patients, evaluates the relationship between blood lipid and sudden sensorineural hearing loss
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