Abstract
PurposeTo evaluate the effectiveness and safety of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during chemoradiotherapy in patients with cervical cancer.MethodsFrom August 2018 to April 2020, 60 patients who were pathologically confirmed as cervical cancer were randomly divided into two groups at a ratio of 2:1: PEG-modified-rhG-CSF experimental group and control group. The primary endpoints were the incidence of grade 3–4 neutropenia. Secondary endpoints included the duration of grade 3–4 neutropenia, the incidence of grade 4 neutropenia, the incidence of febrile neutropenia (FN), delay rate of chemotherapy, prolonged time of chemotherapy, time to complete radiotherapy and safety.ResultsThe incidence of grade 3–4 neutropenia in the experimental group was significantly lower than the control group (10% vs. 77.78%, P < 0.001). However, there was no statistical significance between the two groups in the duration of grade 3–4 neutropenia (3.75 days vs. 5.07 days, P = 0.871). The experimental group was better than the control group in the incidence of grade 4 neutropenia, the incidence of FN and delay rate of chemotherapy, and the difference was statistically significant (P < 0.05). Besides, the prolonged time of chemotherapy and the time to complete radiotherapy in the experimental group were less than those in the control group, but the difference was not statistically significant (P > 0.05). The incidence of adverse events in the experimental group and control group were 55.00 and 94.44%, respectively, and the difference was statistically significant (P = 0.003).ConclusionPEG-rhG-CSF preventive treatment used in the course of chemoradiotherapy for patients with cervical cancer can reduce the incidence of neutropenia and improve the incidence of delayed chemotherapy cycles.Trial registrationClinicalTrials.gov, NCT04542356. Registered 9 September 2020 - Retrospectively registered.
Highlights
Cervical cancer is the third most common cancer among women in the world, and the most common cancer among women in Eastern and Central Africa [1, 2]
Neutropenia caused by chemoradiotherapy is often treated with recombinant human granulocyte colony stimulating factor in clinical practice [5,6,7]
polyethylene glycol (PEG)-recombinant human granulocyte colony stimulating factor (rhG-CSF) mainly acts on hematopoietic cells, including promonocytes, eosinophils, lymphocytes, erythrocytes, and megakaryocytes, by binding to G-CSF receptor on the cell surface, thereby stimulating cell proliferation, differentiation, and activation of terminal cell functions, without altering the aggregation and bind pattern compared with rhG-CSF [9]
Summary
Cervical cancer is the third most common cancer among women in the world, and the most common cancer among women in Eastern and Central Africa [1, 2]. Neutropenia caused by chemoradiotherapy is often treated with recombinant human granulocyte colony stimulating factor (rhG-CSF) in clinical practice [5,6,7]. PEG-rhG-CSF for primary prevention can benefit patients, most of the evidence comes from chemotherapy, there are few clinical practice studies on concurrent chemoradiotherapy [13,14,15]. This current study firstly analyzed the efficacy and safety of PEG-rhG-CSF in the prevention of neutropenia caused by chemoradiotherapy in patients with cervical cancer. The results may provide a basis for the clinical application of PEG-rhG-CSF in the treatment process of chemoradiotherapy cycle in patients with cervical cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
