A clinical data analysis of 92 male idiopathic hypogonadotropic hypogonadism patients

Abstract

Objective To analyze the clinical features,diagnosis and treatment of male idiopathic hypogonadotropic hypogonadism (IHH). Methods Clinical data of 92 male IHH cases were analyzed retrospectively. Results The mean age at evaluation was 21.0 ± 3.2 yrs,and 52 patients were diagnosed with Kallman syndrome (KS; IHH with anosmia/hyposmia) while the remainder were normosmic IHH (nIHH).All had normal radiological imaging of the hypothalamic and pituitary areas.The level of serum LH,FSH and T was low,and the clinical parameters (development of secondary sexual characteristics,sexual function,and serum testosterone levels.) were significantly improved after hormone replacement therapy.Conclusions Diagnosis and differential diagnosis of IHH can be clearly defined based on clinical features and laboratory results.Hormone replacement therapy is an effective treatment option. Key words: Idiopathic hypogonadotropic hypogonadism; Kallman syndrome; Gonadorelin