Abstract
this research examines a clinical case of erythema multiforme in a 5-year-old child,which was triggered by HSV-1. Clinically, the child presented with a fever of 37.5–38.0°C, itching,and a papular-vesicular rash with ring-shaped hyperemia around the vesicles on the face, trunk, limbs,and edema. Instrumental and laboratory investigations did not reveal any abnormalities. The bloodserum analysis detected positive Ab IgG HSV1/2 (qualitative method) with a value of 24.7 S/CO anda dubious result for Ab IgM HSV 1/2 , indicating the presence of a herpes infection. Considering theclinical, laboratory, and instrumental findings, a differential diagnosis was required to distinguish
 between erythema multiforme triggered by HSV-1 and chickenpox in order to prescribe the appropri-ate treatment and prevent complications.
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