Abstract
A clinical case of 48-year-old man with recurrent thrombosis of small pulmonary arteries (PA) has been described in the article. Hereditary and acquired thrombophilia associated with mutations of plasminogen activator inhibitor (heterozygote of the PAI-1 4G / 5G polymorphism) and platelet fibrinogen receptor (heterozygote of the ITGB3 Leu33Pro polymorphism), hyperhomocysteinemia, and hypercholesterolemia was diagnosed. The diagnosis was confirmed by measurement of blood homocysteine and cholesterol levels, and molecular investigation of gene polymorphism mentioned above. PA thrombosis and thrombus location were detected using contrast-enhanced chest computed tomography. Conservative treatment resulted in clinical and radiological improvement.
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