Abstract
Idiopathic intracranial hypertension (IIH) is one of the chronic causes of elevated intracranial pressure with no evident cause in neuroimaging and normal CSF analysis. It primarily affects overweight women of childbearing age.Aim of workTo describe the clinical picture of IIH, neuroimaging and response to treatment after 3 months follow up in a sample of Egyptian patients.Patients and methodsThis was a prospective study carried out on 25 patients presented at Alexandria University Hospital with symptomatology of IIH. All the patients were subjected to complete history taking, neurological examination, fundus examination, lumbar puncture, and MRI brain and MR cerebral venography. The patients were followed-up for 3 months for assessment of treatment response.ResultsPatients’ ages ranged from 1 0to 50 years, with a mean BMI 32.32 ± 5.28 kg m2. Headache was the presenting manifestation in 100% of the patients. About 60% of the sample were either misdiagnosed or had a delayed diagnosis. There was a significant positive correlation between CSF opening pressure (r = 0.504, p = 0.010), severity of headache (r = 0.472, p = 0.017) and grade of papilledema. Optic hydropes and empty sellaturcica were the most common MRI abnormalities occurring in 95.8% and 70.8%, respectively. Only 30% of the cases had normal MRV. Stenosis at genu junction and focal stenosis at transverse sinus occurred in 24% and 20% of the cases, respectively. Combined medical and serial lumbar puncture were the most effective line of therapy in the recruited patients.ConclusionHeadache is the most common presentation of IIH, and its severity is positively correlated with papilledema grade. CSF pressure is also positively correlated with papilledema grade.
Highlights
Idiopathic intracranial hypertension (IIH) is one of the chronic causes of elevated intracranial pressure with normal cerebrospinal fluid (CSF) analysis and without any evident cause in neuroimaging [1]
Headache is the most common presentation of IIH, and its severity is positively correlated with papilledema grade
CSF pressure is positively correlated with papilledema grade
Summary
Idiopathic intracranial hypertension (IIH) is one of the chronic causes of elevated intracranial pressure with normal cerebrospinal fluid (CSF) analysis and without any evident cause in neuroimaging [1]. There are several proposed mechanisms for IIH such as parenchymal edema, increased cerebral blood volume, excessive cerebrospinal fluid (CSF) production, venous outflow obstruction, and compromised CSF resorption. Headache is the most common presentation in most of patients with IIH. Headache profile of IIH is not specific as it mimics the primary headaches with variable severity and duration. Patients present with symptoms as diplopia, blurred vision, transient visual obscurations, tinnitus, and visual loss. Other symptoms such as cervical and back pain, dizziness, nausea, and vomiting may be present [3]
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