Abstract
Pseudocholinesterase is essential for the rapid breakdown of succinylcholine. If pseudocholinesterase is quantitatively or qualitatively deficient, prolonged apnoea may result after administration of succinylcholine. Normal pseudocholinesterase activity is dependent upon allelic genes Eiu. There now appear to be two atypical variant alleles and a silent allele. In anaesthetic practice the homozygous atypical pseudocholinesterase variants may be expected to be encountered with a frequency of about 1:3000.
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