A clinical analysis on 16 pregnant women with severe hepatitis

Abstract

Objective To investigate the obstetric characteristics and the timing and way of delivery in pregnancy women with severe hepatitis.Methods The clinical data on 16 pregnancy women with severe hepatitis who had been treated during 2001 to 2011 were retrospectively reviewed.The women were divided into two groups based on methods of treatment.Group A (7 women from 2001 to 2005) received comprehensive medical treatment; and group B (9 women from 2006 to 2011) received therapies for improvement in coagulation function (infusions of cryoprecipitate,plasma,and fibrinogen) and Cesarean section to terminate pregnancy (stillbirth in two women).Results In group A,4 of the 7 (57.2％) women were dead and 3 (42.8％)neonates survived; while in group B,one of the 9 (11.1％) woman was dead and 7 (66.7％) neonates survived.Conclusions Pregnancy complicated by severe hepatitis commonly occurs during the third trimester of pregnancy,with a dangerous onset,fewer complications,and a higher mortality rate.Abnormal coagulation function is the most common cause of postpartum hemorrhage,which leads to exacerbations and even death in pregnant women with severe hepatitis.Active comprehensive treatment included correcting coagulation function quickly and terminating pregnancy timely is the key to reducing maternal mortality.Artificial liver support system is an effective way to improve the survival rate. Key words: Pregnancy; Severe hepatitis; Timing and way of delivery