A clinical analysis of 8 cases of allergic bronchopulmonary aspergillosis

Abstract

Objective To study the recurrence cause of allergic bronchopulmonary aspergillosis (ABPA) during the treatment.Methods The clinical data of 8 patients with ABPA in the first affiliated hospital of Zhengzhou university from August 2011 to August 2012 were retrospectively analyzed.Results There were 5 males and 3 female.All of them were given glucocorticoids and itraconazole.Five patients were regularly followed,and one of them recurrented after six weeks.Three patients weren' t follow-up recurrented after 2 to 3 months.Patients gained good effect (group A) and recurrent patients (group B) was compared,then the recurrence causes of group B was analyzed.Patients in group A in the follow-up period were given reduced dose of prednisione [initial dose was 0.5 mg/(kg · d)],and were given itraconazole at the same time.In group B,1 case regularly follow-up readmission in 6 months for contact mould on work.One case disabled prednisone for the side effects,one patient reduced the prednisone and disabled in 1 mnonth,both continued to take itraconazole.One patient stopped using itraconazole after 1 month.Conclusions Patients of ABPA will be rapidly relieved after using glucocorticoids,combined with antifungal treatment obtain a good therapeutic effect,only use one of them may increase the risk of recurrence.Discontinuation suddenly and erratic application of the glucocorticoids are important factors of recurrence,even if the antifungal treatment can' t change it,the correct application of glucocorticoids is the foundation for patients with ABPA.Also a high concentration aspergillus environment is an important factor for the recurrence of ABPA. Key words: Allergic bronchopulmonary aspergillosis ; Itraconazole ; Glucocorticoids ; Recurrence