A Click Strategy for the Synthesis of Fluorescent Pyrimidinone‐Triazole Hybrids with CDK2 Selectivity in HeLa and A549 Cell Lines

Abstract

AbstractConcise synthesis of a series of fluorescent pyrimidinone‐triazole hybrids is described. All the synthesized compounds were evaluated for their CDK2 binding affinity based on molecular docking and found to be moderately high score. The molecular docking results were experimentally validated by cytotoxicity evaluation against human cervical cancer cell line HeLa cells and western blot analysis. This new class of CDK2 inhibitors could be promising leads for further drug development as anticancer agents. The molecules also showed fluorescence emission with Stokes shift values up to 187 nm.