A Clean, Simple, and Efficient Synthesis of 2-Substituted Aryl (Indolyl) Kojic Acid Derivatives by Kaolin/Ag Nanocomposite as a Reusable Catalyst: A Green Protocol

Bahareh Sadeghi,Mohammad Reza Shahedi

doi:10.1155/2013/418969

Abstract

Kaolin/Ag nanocomposite (kaolin/Ag nanocomposite) was synthesized in a nanoreactor by the calcination of the precursor at high temperature and was shown to efficiently catalyze the one-pot, three-component reaction of an aromatic aldehyde, kojic acid, and indole derivatives under solvent-free conditions to afford the corresponding 2-substituted aryl (indolyl) kojic acid derivatives in high yield.

Highlights

Nanocomposite is a new class of composites in which the dimensions of the material are in the order of nanometers
In continuation of our investigations of the application of solid acids in organic synthesis [12,13,14,15,16], we have investigated the synthesis of Kaolin/Ag nanocomposite as a catalyst and applied for the synthesis of 2-substituted aryl kojic acid derivatives
Silver ion is reduced by methanol in an alkaline solution while the temperature was fixed to 25∘C during the reaction

Summary

Introduction

Nanocomposite is a new class of composites in which the dimensions of the material are in the order of nanometers. Because of this nanometer size characteristic, nanocomposites possess superior properties than the conventional composites such as thermal stability, high surface areas, and mechanical and catalytic properties [1,2,3]. The 3-substituted indole moieties are included in numerous natural products and they are dominant molecules in medicinal chemistry [8, 9]. Due to the vast medicinal utility of kojic acid and 3-substituted indole derivatives, the introduction of a mild, efficient, and selective method to synthesize these compounds is still needed. In continuation of our investigations of the application of solid acids in organic synthesis [12,13,14,15,16], we have investigated the synthesis of Kaolin/Ag nanocomposite as a catalyst and applied for the synthesis of 2-substituted aryl (indolyl) kojic acid derivatives

Experimental

Results and Discussion

Conclusion