A Classification-Based Approach to Estimate the Number of Resting Functional Magnetic Resonance Imaging Dynamic Functional Connectivity States.

Abstract

Aim: To determine the optimal number of connectivity states in dynamic functional connectivity analysis. Introduction: Recent work has focused on the study of dynamic (vs. static) brain connectivity in resting functional magnetic resonance imaging data. In this work, we focus on temporal correlation between time courses extracted from coherent networks called functional network connectivity (FNC). Dynamic FNC is most commonly estimated using a sliding window-based approach to capture short periods of FNC change. These data are then clustered to estimate transient connectivity patterns or states. Determining the number of states is a challenging problem. The elbow criterion is one of the widely used approaches to determine the connectivity states. Materials and Methods: In our work, we present an alternative approach that evaluates classification (e.g., healthy controls [HCs] vs. patients) as a measure to select the optimal number of states (clusters). We apply different classification strategies to perform classification between HCs and patients with schizophrenia for different numbers of states (i.e., varying the model order in the clustering algorithm). We compute cross-validated accuracy for different model orders to evaluate the classification performance. Results: Our results are consistent with our earlier work which shows that overall accuracy improves when dynamic connectivity measures are used separately or in combination with static connectivity measures. Results also show that the optimal model order for classification is different from that using the standard k-means model selection method, and that such optimization improves cross-validated accuracy. The optimal model order obtained from the proposed approach also gives significantly improved classification performance over the traditional model selection method. Conclusion: The observed results suggest that if one's goal is to perform classification, using the proposed approach as a criterion for selecting the optimal number of states in dynamic connectivity analysis leads to improved accuracy in hold-out data.