A Clandestine Approach to the Synthesis of Phenyl-2-Propanone from Phenylpropenes

Abstract

Abstract A number of published syntheses for the manufacture of controlled substances appear to be impractical for the average clandestine laboratory. A closer inspection of these syntheses may reveal modifications which greatly simplify their application. An excellent example of this is the preparation of phenyl-2-propanone (P-2-P) from allylbenzene. In the prototype published method, oxygen is introduced into the reaction vessel by using a tank of compressed oxygen with a balloon for a gas reservoir. In our modification, oxidation is accomplished with a 30% hydrogen peroxide solution. P-2-P has been prepared by both methods and a comparison made of the reaction mixtures at various times during their synthesis. Additionally, propenylbenzene, a by-product of these reactions, can be converted to P-2-P by modification of a second synthesis. Gas chromatography and nuclear magnetic resonance spectral data are presented for each method.