A Chronobiologic Theory of Fibromyalgia

Abstract

The paper reviews the evidence in favour of a chronobiologic theoretical model of fibromyalgia. Findings: The physiology and behaviour of sleep and wakefulness are important components of the features of fibromyalgia. Detailed analyses of recurrent changes over time in the patterns of these fundamental brain functions and symptoms provide evidence for central nervous system mechanisms that underlie the disorder. Consistent with the chronobiologic theory, the constellation of diffuse pain, nonrestorative sleep, fatigue and dpression is shown to be the result of altered biologic rhythms that involve diurnal physiologic functions, seasonal environmental influences, and social-behavioral disturbances. Conclusions: The chronobiologic theory stresses the importance of temporal variation and the factors that influence and govern recurrent patterns of biologic functions and behavior that determine health and the evolution of the illness. Finally, the chronobiologic theory of fibromyalgia allows for an integrated ...