Abstract
Through self-assembly, the preparation of trinuclear carbene complexes from polycarbene ligands and silver(I) ions has been investigated. Reactions between 1,3,5-tris(bromomethyl)benzene with three equimolar N-substituted alkyl benzimidazole yielded the formation of numerous aromatic backbone scaffolds tris-benzimidazolium salts, H3L (1–5). Further reaction of the salts with Ag2O resulted in the formation of bis tri-NHC trinuclear silver(I) complexes with the formula of [Ag3L2]·3PF6 (6–10) (where NHC = N-heterocyclic carbene). Structure elucidation from single-crystal X-ray diffraction data revealed that complex 9 is a cylindrical-like structure featuring three silver(I) atoms sandwiched between two tricarbene ligands with the aromatic backbone of each ligand arranged in eclipsed conformation with the formula of [Ag3L2]·3PF6·3MeCN (9). The anticancer study of the salts and complexes was carried out using Etoposide as the positive control. Subsequently, only complexes 6–10 were found to have potential anticancer agents, with 6 and 8 being more active than the positive control.
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