A chemoenzymatic approach to (R)-tetrahydro-5-oxo-2-(2-hydroxyethyl)furan, a useful chiral synthon: Application to the synthesis of (S)-4-hexanolide, pheromone antipode of [formula omitted

Abstract

A synthesis of versatile chiral synthon 6 has been accomplished via a baker's yeast mediated reduction, which was further utilized for the synthesis of 8, pheromone antipode of stored grain pest.