Abstract
BackgroundCardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients.MethodsWe searched the following databases: PubMed, Scopus, ISI Web of Science, and Google Scholar. Relevant observational and controlled trials were explored from inception by April 2020. The quality of the articles was assessed using the Newcastle-Ottawa Scale (NOS).ResultsFinally, five cohort studies (n = 201 participants in total) were eligible for including in the meta-analysis. The results of this meta-analysis showed that although the baseline serum cortisol levels were higher in survivors of cardiac arrest compared with non-survivors, the differences between groups do not reach a significance level (Hedges’ g = 0.371, 95% CI, −0.727, 1.469, P value = 0.508). Between-study heterogeneity was statistically significant (Cochrane Q test: P value < 0.001, I2 = 89.323).ConclusionsThe result of the present meta-analysis was suggestive of a higher baseline serum cortisol levels in survivors of CPA. Future randomized controlled studies with a large sample size will determine the exact relationship between adrenal reservation and the eventual outcome of patients with CPA.Systematic review registrationPROSPERO CRD42018085468
Highlights
Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality
CPA is an abrupt loss of cardiac func‐ tion which can occur in a person without underlying heart diseases [4]
PI(E)CO question We considered serum cortisol level for the adrenal reserve assessment in the patients resusci‐ tated after both in-hospital and out-of-hospital CPA
Summary
Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients. Cardiopulmonary arrest (CPA), known as cardiac arrest, is a severe and potentially fatal condition. CPA is associated with high mortality [1]. Association National Registry of Cardiopulmonary Resuscitation report, the discharge rate of CPA patients is 17.6% [2]. CPA may lead to the following dysrhythmia: ventricular fibrillation, pulseless ventricular tachycardia, and asystole. CPA is an abrupt loss of cardiac func‐ tion which can occur in a person without underlying heart diseases [4]. The majority of CPAs are not sudden in the hospitalized patients, as 50‐84% of these
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