Abstract
Mediastinal germ cell tumours (MGCTs) are rare malignancies found in the paediatric age group. Unlike the majority of germ cell tumours, non-seminomatous primary MGCTs tend to have a poor prognosis, and multiple additional malignancies have been reported in these patients. Approximately 6% will develop haematological malignancies, unrelated to prior treatment, which are associated with an extremely poor prognosis.1 These leukaemias seem to have a shared clonal origin with the MGST, possibly explaining their apparent resistance to standard leukaemia treatments.
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