Abstract
Donna Wilcock will discuss the inflammatory factors associated with the failure of vascular clearance of Aβ. Hyperhomocysteinemia (HHcy) models small vessel disease in mice, and leads to a shift in amyloid distribution, increasing vascular amyloid deposition (CAA), when induced in APP/PS1 mice. HHcy induces a robust pro-inflammatory response in the brain that is known to result in reduced parenchymal amyloid deposition. However, the vascular injury induced by the HHcy negatively affects the perivascular drainage components including smooth muscle cells and astrocytic end-feet. This likely results in the accumulation of AB at the vasculature as CAA. These findings add to our understanding of the determinants of amyloid distribution.
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