A cell model about symmetric and asymmetric stem cell division

Abstract

We construct a multi-stage cell lineage model including self-renewal, apoptosis, cell movement and the symmetrical/asymmetrical division of stem cells. The evolution of cell populations can be described by coupled reaction–diffusion partial differential equations, and the propagating wavefront speeds can be obtained analytically and verified by numerical solutions of the equations. The emphasis is on the effect of symmetric/asymmetric division of stem cells on the population and propagating dynamics of cell lineage. It is found that stem cells’ asymmetric cell division (ACD) can move the phase boundary of the homogenous solution of the system. The population of the cell lineage will be promoted in presence of ACD. The concentration of stem cells increases with ACD but that of differentiated daughter cells decreases with ACD. In addition, it is found that the propagating speed of the stem cells can be evaluated with ACD. When the daughter cells move fast to a new space, stem cells can catch them up through increasing ACD. Our results may suggest a mechanism of collective migration of cell lineage through cooperation between ACD of stem cells and fast diffusion of the daughter cells.