Abstract
An intermediate in the replication of three different staphylococcal plasmids is a catenated mixed dimer consisting of an open circular and a closed circular monomer. The mixed dimer, having a buoyant density intermediate between that of circular duplex and relaxed DNA's in dye-buoyant density gradients is rapidly and transiently labeled and appears to be a precursor of mature closed circular monomers. Whether it is an obligatory intermediate or a step on an alternate replication pathway remains uncertain.
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