Abstract
Deng and co-workers report the catalytic asymmetric Darzens reaction between cyclic and acyclic α-chloro ketones and aliphatic as well as aromatic aldehydes. A systematic tuning of cinchona alkaloid derived quaternary ammonium salts revealed structure 1 as the phase-transfer catalyst of choice. In the presence of lithium hydroxide as stoichiometric base, catalyst 1 provides the desired products in high yields and high enantioselectivities.
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