Abstract
Zirconocene catalyzed cyclization of 2-(5-methoxy-3-penten-1-yl)styrene in the presence of organomagnesium reagents was studied. The cyclization proceeded in high isolated yields (up to 84%) with excellent trans-selectivity (>98%), which is unusual for the formation of cyclohexane derivatives. Catalytic cyclization in the presence of Cp 2ZrCl 2 proceeded as well with similar results. The reaction with ( R, R)-(EBTHI) 2ZrCl 2 gave a cis/trans mixture of 5 in low yield and poor ee.
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