Abstract

AbstractA concise and efficient one‐pot sequential approach for the synthesis of modified isoflavone was developed from a reaction of 3‐formylchromones, malononitrile, various α,α‐dicyanoolefines, using Et3N as the base, and EtOH as the solvent, in good yield. The value of this method lies in its short reaction time, convenient purification, no need for a metal catalyst, excellent efficiency, and green solvent. This synthesis involves a Knoevenagel condensation/carbanion formation/ring closure, and finally, an elimination to obtain the respective isoflavonoid derivatives.

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