Abstract
ABSTRACTPurposeThe biomechanical properties of the polyurethanes implant material derived from castor oil plant (Ricinus communis) were evaluated in a noncritical bone defect model in rat tibia.MethodsAfter three weeks of the implant application, the tibias were tested by means of the biomechanical three-point flexion test and resistance, rigidity, energy at maximum load and maximum energy were evaluated. Nonparametric statistical analysis was performed.ResultsIt was found that the group that received the implant behaved the same as the intact control group and also showed a significant increase in maximum load compared to the spontaneous repair group.ConclusionsOur results indicate that the tibias with the implant material in a noncritical bone defect recover normal biomechanical parameters in less time than spontaneously.
Highlights
Loss of bone segments causes human and animal health problems
Three groups of seven rats each were randomly selected and organized in the following manner: G-1, untreated age- and weight-matched control rats; G-2, rats with an unfilled right tibia defect, rats were allowed to recover for three weeks to address bone defect spontaneous repair; G-3, rats with a right tibia defect filled with the test implants, rats were left to recover for three weeks
The rats were in general good health, the experimental limb was bearing rat’s weight without limping and showed an increase in body weight according to their age and strain
Summary
Loss of bone segments causes human and animal health problems. The most frequent causes of loss of bone segments are resection of tumors, bone infections and trauma. The use of existing materials, the development and use of new materials to optimize, accelerate, promote and facilitate the repair of bone defects, both those that repair themselves spontaneously (noncritical), and those that require medical intervention for their repair (critical) is of high importance for orthopedic surgery, dental surgery and maxillofacial surgery[1,2,3]. The implant together with mesenchymal stem cells revealed that it does not affect cell adhesion or proliferation and increases the formation of mineralization nodules[6]; it was decided to evaluate its effect on repair of a noncritical bone defect in rat tibia through biomechanical analysis
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