A case-control study on the risk factors of recurrence and metastasis in breast cancer

Abstract

Objective To explore the risk factors of breast cancer recurrence for the cause exploration and prevention of the disease. Methods With matched case-control method, a survey was conducted among survival cases of histologically diagnosed breast cancer patients in Southern hospital from January 2004 to December 2007 in Guangzhou city. The survival cases were divided into case group and control group according to the inclusion criteria. Unconditional logistic model was used to analyze the data. Results Multiple factors logistic regression analysis showed mental stimulations [OR =10.926, 95%CI (5.041-23.682) ], oral contraceptive pills history [OR=2.634, 95%CI(1.548-4.482) ], benign breast disease history [OR=5.183, 95%CI(2.100-12.790) ], human epiderma growth factor receptor-2 (HER2) positive [OR= 2.257, 95%CI (1.326-3.843) ], lymph node metastasis [OR=2.021, 95%CI (1.272-3.212) ], distant metastasis [OR=3.718, 95%CI (2.125-6.503) ] might be associated with the increasing breast cancer recurrence risk. Regular exercise [OR=0.460, 95%CI(0.234-0.905) ], low stage of disease [OR=0.106, 95%CI(0.022-0.498) ], breast nursing time [OR=0.053, 95%CI(0.009-0.316) ], dietary intake of soy isflavones[OR=0.154, 95%CI (0.032 -0.745) ] might be associated with the decreasing breast cancer recurrence risk. Conclusions Clinical medical staff should take attention to the breast cancer who had benign breast disease history to ensure timely check-ups, early detection, early diagnosis and early treatment. Improving physical and psychological quality, reducing oral contraceptive pills, prolonging breast nursing time, and increasing dietary intake of soy isflavones were important to the prevention of breast cancer recurrence. Key words: Breast neoplasms; Recurrence; Risk factors; Case-control studies