A case-control study on the duration of sleeping and cerebral infarction

Abstract

To explore the relationship between duration of sleeping and cerebral infarction. A case-control study involved 1037 cerebral infarction patients admitted by the Second Affiliated Hospital of Harbin Medical University,December 2011-December 2012 as cases. Another 1205 adults free from cerebro-vascular diseases who had undergone physical examination in the hospital at the same period, were served as controls. All the subjects were interviewed with unified questionnaire. Chi-square test, u-test and multivariate logistic regression analysis were performed. After adjustment for potential confounding factors including age, sex, body mass index, wrist-hip ratio, smoking, alcohol intake, hypertension, diabetes mellitus, coronary artery disease and lipid parameters, data from the multivariate logistic regression analysis showed that the risk of cerebral infarction was greater in people who slept less than 6 hours per night than those who slept between 6 hours and 8 hours per night, with an odds ratio (95% CI)as 2.81 (95% CI:1.68-4.70). There was no significant association between factor as 'sleeping longer than 8 hours/pre day' and cerebral infarction. Through the subgroup analysis, data showed that the association between 'shorter than 6 hour sleep/night' and cerebral infarction consistently existed, across the categories of sex, and the degree of association was greater in women than in men, with the odds ratio as 5.58 (95% CI: 1.78-17.52) and 2.00 (95% CI:1.10-3.64) respectively. Short sleeping duration might increase the risk of developing cerebral infarction.