A Case with Three Primary Malignant Tumors, such as Malignant Lymphoma, Carcinomas of the Bladder and the Colon

Abstract

We report a 66-year-old female with multiple primary malignant tumors: malignant lymphoma, transitional cell carcinoma of the urinary bladder, adenocarcinoma of the colon and anaplastic carcinoma of neck originated in the unknown site. Firstly, the patient was treated with antitumor agents for malignant lymphoma. During the course of treatment, carcinoma of the bladder was found by urologidt since hematuria occurred, and she was also treated with 60Co irradiation after intra-arterial infusion of CDDP for carcinoma of the bladder. Nine months later, swelling of cervical, intraperitoneal and inguinal lymph nodes were noticed, and some of them were metastasis of anaplastic carcinoma, but the origin of them was unknown. Additionally, she complained of fullness of lower abdomen, and endoscopic examination revealed the carcinoma of the colon, and died of cachexy on 30 months after initial chemotherapy.We have had 51 cases of multiple primary tumors of the head and neck in our Department from 1978 to 1987. The incidence rate of these patients in all the cases with head and neck tumors was 5.9%, and it was higher than those reported elswhere. The clinical problems concerning diagnosis and treatment for multiple malignant tumors was discussed briefly.