A Case Study on Primary Osteosarcoma of the Breast

Juan Manuel Pazos Guarin

doi:10.4172/2572-5130.1000148

Abstract

Primary osteosarcomas of the breast are very rare neoplasias, accounting for less than 1% of breast carcinomas and 12.5% of breast sarcomas, with only 50 cases reported in the last 50 years. The mechanism of tumorigenesis is not clear, it’s postulated that it is formed from totipotential cells of the stroma. It´s also has been postulated that previous radiotherapy may induce formation of breast sarcoma like ostegenic sarcomas. We report a case of a 93 year old female with a history of left mucinous breast cancer treated with adjuvant chemotherapy and radiotherapy and breast conserving surgery. Five years later, another tumor emerged in the left breast which was diagnosed like osteosarcoma. This case study traces that osteosarcoma of the breast may occur in a patient with previous radiotherapy.

Highlights

Primary osteosarcomas of the breast are very rare neoplasias
We report radiological features of primary osteosarcoma of the breast
We present the case of a 93-year-old woman with a history of left mucinous breast cancer treated with adjuvant chemotherapy and radiotherapy and breast-conserving surgery five years ago

Summary

Introduction

Primary osteosarcomas of the breast are very rare neoplasias. It is a very aggressive neoplasm, with a high probability of recurrence and metastatic involvement, especially hematogenous. We report radiological features of primary osteosarcoma of the breast. In this case report, we present the case of a 93-year-old woman with a history of left mucinous breast cancer treated with adjuvant chemotherapy and radiotherapy and breast-conserving surgery five years ago. At follow up appointment physical examination revealed a palpable left breast mass. Blood flow is seen in the intracystic mass (Figure 3). Computed tomography scan was performed for seeking metastasis which showed a circumscribed mass in the left breast with strong contrast enhancement and internal cystic change (Figure 4).

Discussion

Findings

Conclusion