Abstract
Organic synthesis on solid-phase resins requires new applications of nondestructive analytical tools to monitor the progress of reactions. Herein we describe our novel approach to validate a five-step reaction sequence on resin. We have developed a protocol list that allows us to follow reactions step-by-step using different analytical procedures in the order of increasing experiment time. Results from these various techniques for each reaction step are contrasted and compared. The key to achieve definitive analytical data for the entire reaction sequence is the combined application of more than one analytical technique.
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