Abstract
Introduction: Acromegaly is a rare disorder with an approximate incidence of 3-11 new cases per million of population per year. It’s associated to an increased risk of benign and malignant neoplasms, especially thyroid, colorectal and breast cancer. Case Series: We report 2 cases of two patients followed in our department for acromegaly who were diagnosed also with papillary thyroid carcinoma. Discussion and Conclusion: IGF1 inhibit cell apoptosis and promote cell proliferation in multiple tissues. An association between IGF1 levels and cancer risk such as thyroid cancer was detected. Careful screening for thyroid cancer, with periodic thyroid examination, should be an important part of the management of acromegalic patients. Keywords: Acromegaly - malignancy - papillary thyroid carcinoma
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