Abstract

ABSTRACT Since its outbreak in Wuhan, Hubei Province China, 2019-coronavirus infected disease (COVID-19) had been widely spread all over the world, the control of which calls for a better understanding of its epidemiology and clinical characteristics. We included 12 confirmed cases of COVID-19 in First Affiliated Hospital of Jilin University from 23 January 2020 to 11 February 2020, which were retrospectively analyzed for epidemiological, demographic, clinical, laboratory, and radiological features. All the patients were confirmed by nucleic acid detection, the average age of whom was 45.25 years (range, 23–79 years). Most patients had a history of Wuhan traveling or had contact with Wuhan travelers or infected cases. Obvious family cluster was observed. Clinical manifestations included fever (12/12), fatigue (10/12), cough (6/12), sore throat (4/12), headache (3/12), and diarrhea (2/12). Only three out of eight patients had pneumonia manifestation on radiography. Most patients had a normal white blood cell (WBC) count and normal or reduced lymphocyte (LY) count. Pneumonia changes were observed in all the four patients who underwent a chest CT scan. Only one elderly patient developed severe pneumonia, while all the rest were mild disease and had a self-limiting course.

Highlights

  • Since the outbreak of a novel coronavirus pneumonia in Wuhan, Hubei Province China in December 2019, the disease has rapidly spread to many cities within China and globally [1,2]

  • The World Health Organization (WHO) has termed the pneumonia caused by SARS-CoV-2 as 2019-coronavirus infected disease (COVID-19) [3,4]

  • Most of the patients had a history of traveling to Wuhan or to people who had traveled to Wuhan (PTs 2–7), or to patients with confirmed infections (PT 11, PT 12)

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Summary

Introduction

Since the outbreak of a novel coronavirus pneumonia in Wuhan, Hubei Province China in December 2019, the disease has rapidly spread to many cities within China and globally [1,2]. The cause is the novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; formerly known as 2019-nCoV) [3], and it is capable of rapid human-to-human transmission. The World Health Organization (WHO) has termed the pneumonia caused by SARS-CoV-2 as 2019-coronavirus infected disease (COVID-19) [3,4]. The number of suspected or confirmed cases and mortalities due to COVID-19 has continued to rise in Wuhan as well as in many other areas [7]. By 16 February 2020, Jilin Province had reported 89 cases confirmed by nucleic acid detection, among which 12 were diagnosed at First Affiliated Hospital of Jilin University

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