Abstract
In this case report, a rare case of Pemphigoid Gestationis at 33 weeks’ of gestation is presented and the related literature is briefly reviewed. A 21-year-old at 33 weeks’ of gestation admitted with the complain of itchy skin lesions on the abdomen, arms and legs. Dermatologic examination revealed urticaria papules and plaques in the abdomen, arms and legs, more intensely around the umbilicus, which range from 1-2 cm diameter to 4-5 cm diameter. Papulovesicular lesions and few erosions were observed especially in the hand and foot dorsals. Spongiosis on epidermis, intracellular and subepidermal bullae formation, edema on papillary architecture and inflammatory infiltrate composed of mononuclear cells and eosinophils around the perivascular ares of the upper dermis were seen in histological examination. Direct immunofluorescence of perilesional skin showed linear deposition of complement (C3) along the basement membrane zone. The preliminary diagnosis of pemphigoid gestationis was confirmed by histopathologic findings. Pemphigoid gestationis is a rare autoimmune bullous dermatosis that begins in the second or third trimester of pregnancy. Healing occurs weeks after birth. It occurs more severely in subsequent pregnancies. Its main treatment is systemic steroid and antihistamine administration. A multidisciplinary approach both in dermatological and gynecological terms is required for the diagnosis, treatment and course of the disease.
Highlights
In this case report, a rare case of Pemphigoid Gestationis at 33 weeks’ of gestation is presented and the related literature is briefly reviewed
Dermatologic examination revealed urticaria papules and plaques in the abdomen, arms and legs, more intensely around the umbilicus, which range from 1-2 cm diameter to 4-5 cm diameter
Spongiosis on epidermis, intracellular and subepidermal bullae formation, edema on papillary architecture and inflammatory infiltrate composed of mononuclear cells and eosinophils around the perivascular ares of the upper dermis were seen in histological examination
Summary
We were consulted by a 33-year-old pregnant woman at the age of 21, who applied to the dermatology outpatient clinic due to itchy skin lesions in the abdomen, arms, legs, hands and feet In her dermatological examination; Urticaria papules and plaques on the abdomen, arms and legs, more intensely around the umbilicus, which ranged from 1-2 cm diameter to 4-5 cm diameter, papulovesicular lesions in the hands and feet, lesions in the target area, and small number of erosions were seen (Figure 1,2,3,4 ). Direct immunofluorescence of perilesional skin showed linear deposition of complement (C3) along the basement membrane zone of the epidermis. With these clinical and histopathological findings, the patient was diagnosed with herpes gestation.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
