Abstract
Background: Out of the various malignant tumours originating from the lymphatic hematopoietic system, lymphoma is one such important entity. It is divided into Non-Hodgkin’s Lymphoma (NHL) and Hodgkin Lymphoma (HL) depending on its cell source. A very rare type of malignant variant of lymphoma is the primary splenic lymphoma, involving exclusively the spleen and splenic hilar lymph nodes. Moreover, splenic marginal zone lymphoma (SMZL) is even more infrequent. SMZL is an uncommon chronic B lymphocyte proliferative disease, which only accounts for about 1–2% of all non-Hodgkin’s lymphoma. The mean age of SMZL incidence is about 65 years. There is no known significant gender predominance. A quarter of patients with early diagnosed SMZL have known to have vague symptoms like abdominal pain and distention; and other patients may be accompanied by loss of weight, malaise, cachexia, splenomegaly, or other manifestations.
 Conclusion: Although, a good prognostic outcome is what is usually expected from most patients of Splenic Marginal Zone Lymphoma who undergo splenectomise, an aggressive transformation leading to a worse direction cannot be ruled out. SMZL is very challenging to be diagnosed pre-operatively due to the lack of specificity in clinical presentation.
Highlights
Though Non-Hodgkin’s Lymphoma (NHL) is known to have an aggressive nature, splenic marginal zone lymphoma (SMZL) is relatively indolent with a favorable prognosis [8]
Immunohistochemistry was advised for confirmation which was reported as Splenic Marginal Zone Lymphoma (SMZL) with lymph node involvement and liver infiltration
The definitive diagnosis of this condition pre-operatively has been demanding in the early stages of the disease due to the lack of specific clinical features, imaging, or laboratory findings and by the time patients present with symptomatic splenomegaly and cytopenia, the disease has already advanced in course
Summary
A Department of Pathology, Datta Meghe Medical College, Nagpur, India. B Department of Pathology, Jawaharlal Nehru Medical College, Wardha, India. C Department of Medicine, Datta Meghe Medical College, Nagpur, India. This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/71192
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