Abstract

We describe a case of Linezolid-induced severe toxic optic neuropathy in a patient with drug-resistant tuberculosis. Linezolid produced severe toxic optic neuropathy in some who used it for a long time. To the best of our knowledge, the optic neuropathy was completely reversed after omitting Linezolid which is one of the effective drug regimens in his prescription, with significant improvements in eye vision.

Highlights

  • Toxic optic neuropathy has been reported as an uncommon side effect of Linezolid treatment for a longer duration with the majority of cases

  • [1] Staphylococcus aureus bacteria are the most common pathogen isolated in all types and stages of Osteomyelitis, and these strains are not treated by Methicillin a day

  • [5] We present a case of reversible optic neuropathy in a patient with XDR-TB who experienced it after long-term treatment (TB)

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Summary

INTRODUCTION

Occurring in adults. [1,2,3,4,5] various cases have been documented in people of varying ages. Linezolid treatment for extensively drug-resistant tuberculosis (XDR-TB). [1] Staphylococcus aureus bacteria are the most common pathogen isolated in all types and stages of Osteomyelitis, and these strains are not treated by Methicillin a day. MRSAinduced Osteomyelitis is managed with Linezolid, which is active on most MRSA strains. [2] It has been successfully utilized as a long-term treatment for persistent Staphylococcus aureus Osteomyelitis despite its less than ideal safety profile. [3,4,5] the reported neuropathy resulted in blindness with one case found. [5] We present a case of reversible optic neuropathy in a patient with XDR-TB who experienced it after long-term treatment (TB). The reversibility of optic nerve involvement has been proven in the visual examination after treatment has ended

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