Abstract
BackgroundCellulosimicrobium cellulans is a gram-positive filamentous bacterium found primarily in soil and sewage that rarely causes human infection, especially in previously healthy adults, but when it does, it often indicates a poor prognosis.Case presentationWe report a case of endocarditis and intracranial infection caused by C. cellulans in a 52-year-old woman with normal immune function and no implants in vivo. The patient started with a febrile headache that progressed to impaired consciousness after 20 days, and she finally died after treatment with vancomycin combined with rifampicin. C. cellulans was isolated from her blood cultures for 3 consecutive days after her admission; however, there was only evidence of C. cellulans sequences for two samples in the second-generation sequencing data generated from her peripheral blood, which were ignored by the technicians. No C. cellulans bands were detected in her cerebrospinal fluid by second-generation sequencing.ConclusionsSecond-generation sequencing seems to have limitations for certain specific strains of bacteria.
Highlights
Cellulosimicrobium cellulans is a gram-positive filamentous bacterium found primarily in soil and sewage that rarely causes human infection, especially in previously healthy adults, but when it does, it often indicates a poor prognosis.Case presentation: We report a case of endocarditis and intracranial infection caused by C. cellulans in a 52-yearold woman with normal immune function and no implants in vivo
Cellulosimicrobium cellulans, formerly known as Oerskovia xanthineolytica, is a gram-positive filamentous bacterium found primarily in soil and sewage that rarely causes human infection, with only approximately 30 cases reported to date
We report a case of endocarditis and intracranial infection caused by C. cellulans in a 52-year-old woman with normal immune function and no implants in vivo
Summary
Cellulosimicrobium cellulans is a gram-positive filamentous bacterium found primarily in soil and sewage that rarely causes human infection, especially in previously healthy adults, but when it does, it often indicates a poor prognosis.Case presentation: We report a case of endocarditis and intracranial infection caused by C. cellulans in a 52-yearold woman with normal immune function and no implants in vivo. Background Cellulosimicrobium cellulans, formerly known as Oerskovia xanthineolytica, is a gram-positive filamentous bacterium found primarily in soil and sewage that rarely causes human infection, with only approximately 30 cases reported to date. Infections occurred mainly in immunocompromised hosts, patients with medically relevant implants, and newborns. We report a case of endocarditis and intracranial infection caused by C. cellulans in a 52-year-old woman with normal immune function and no implants in vivo.
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