Abstract
BackgroundSyndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatremia in hospitalized patients and is often described in patients with small-cell carcinoma of the lung. In this report, we described both Castleman’s disease and lymphoma coexisting in one patient with SIADH.Case presentationA 70-year-old Chinese woman with a history of diabetes mellitus and insulin therapy had severe hyponatremia and gastrointestinal symptoms. Through a series of examinations, common causes such as pulmonary carcinoma were excluded. An abdominal mass was detected by computed tomography. Although the peripheral lymph node biopsy showed the pathological result as Castleman’s disease, the pathology of the abdominal lymph node revealed diffuse large B-cell lymphoma. After chemotherapy, the hyponatremia was treated during a period of follow-up.ConclusionThis patient presented with the rare clinical condition of inappropriate antidiuretic hormone secretion alongside Castleman’s disease and lymphoma. Asymptomatic hyponatremia may persist for some time suggesting that clinical physicians should pay attention to the mild cases of hyponatremia. We also hypothesized that Castleman’s disease is a condition of pre-lymphoma with both having the ability to cause SIADH. The possibility of lymphoma as well as Castleman’s disease triggering the development of SIADH should also be taken into consideration for conducting recurrent biopsies.
Highlights
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatremia in hospitalized patients and is often described in patients with small-cell carcinoma of the lung
This patient presented with the rare clinical condition of inappropriate antidiuretic hormone secretion alongside Castleman’s disease and lymphoma
Asymptomatic hyponatremia may persist for some time suggesting that clinical physicians should pay attention to the mild cases of hyponatremia
Summary
This report describes a rare case, in which an older woman had both Castleman’s disease and lymphoma coexisting with SIADH. Authors’ information MZ is the director of the Department of Endocrinology, Tianjin Medical University General Hospital. HQQ is an Assistant Professor, Division of Epidemiology, Human Genetics and Environmental Sciences at School of Public Health, University of Texas Health Science Center at Houston. Author details 1Department of Endocrinology, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin 300052, China. Author details 1Department of Endocrinology, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin 300052, China. 2Department of Pathology, Tianjin Medical University Cancer Hospital, Huan-Hu-Xi Road, Tiyuanbei, Hexin District, Tianjin 300060, China. 3Department of Surgery, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin 300052, China. 4Department of Hematology, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin 300052, China. 5Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, 1200 Herman Pressler, Houston, Texas 77030, USA
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