Abstract
Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. His symptoms gradually improved, and he regained good control of his voice.
Highlights
Spindle cell carcinoma of the larynx is a rare tumor and comprises 2% to 3% of all laryngeal cancers [1]
Spindle cell carcinoma is considered to be a biphasic tumor that is composed of a squamous cell carcinoma and spindle cell carcinoma with sarcomatous appearance [2]
Since a majority of these tumors are polypoid or pedunculated and tend to cause obstructive symptoms, these tumors are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis
Summary
Spindle cell (sarcomatoid) carcinoma of the larynx is a rare tumor and comprises 2% to 3% of all laryngeal cancers [1]. Squamous cell carcinoma is the most malignant carcinoma of the larynx, and spindle cell (sarcomatoid) tumor is considered a highly malignant variant of squamous cell carcinoma. Spindle cell carcinoma is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance [2]. Since a majority of these tumors are polypoid or pedunculated and tend to cause obstructive symptoms, these tumors are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. The following is a case report of one such patient who presented to our institution with spindle cell (sarcomatoid) carcinoma of the larynx
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