Abstract
A 55-year-old woman's right breast cancer (infiltrating papillotubular carcinoma) was resected. Then she had two more redical resections for other cancers. One was for anal cancer (keratinizing squamous cell carcinoma) two years and nine months later, and another was for lung cancer (moderately differentiated adenocarcinoma) three and a half years after the first operation. Laboratory findings showed an extremly high value of AFP and CEA during the postoperative course. Then the forth cancer was suspected to develop in brain, and she died. Triple malignant neoplasms have gradually increased in incidence, and mainly occurred in men (the male/female ratio is 7 to 3) in 431 cases of Annual of the Pathological Autopsy Cases in Japan since last 24 years. The methods of post operative chemotherapy and radiation for the breast cancer had an influence on the incidence and the sites of the second cancer, in reviewed cases. The factors inducing the multiple primary cancers have to be studied furthermore in future.
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