Abstract
BackgroundUpper tract urothelial carcinoma with pure non-urothelial histology is an exception but variants are present in ~ 25% of cases. Primary upper urinary tract signet -ring cell carcinoma is extremely rare.Case presentationWe report the case of a 65-year-old male diagnosed primary upper urinary tract signet-ring cell carcinoma while underwent percutaneous nephrolithotomy. Radical nephroureterectomy and adjuvant chemotherapy were performed sequentially. The patient is now recovering well with a regular follow-up for more than 1 year.ConclusionsThe upper urinary tract malignancy often appears as a high grade, high stage tumor and has a uniformly poor prognosis, but a timely multimodal management can bring a good outcome.
Highlights
Upper tract urothelial carcinoma with pure non-urothelial histology is an exception but variants are present in ~ 25% of cases
Urothelial carcinomas (UCs) are the fifth most common tumors [7], with the Upper tract urothelial carcinoma (UTUC) accounting for only 5-10% [8, 9]
60% of UTUC are invasive at the time ofdiagnosis
Summary
Upper tract urothelial carcinoma with pure non-urothelial histology is an exception but variants are present in ~ 25% of cases. Background Upper tract urothelial carcinoma (UTUC) with pure nonurothelial histology is an exception but variants are present in ~25% of cases [1, 2], including squamous cell carcinoma and adenocarcinoma. Among the cases mentioned above, upper urinary tract signet ring cell carcinoma (SRCC) is rare [3, 4]. The upper urinary tract malignancy often appears as a high grade, high stage tumor and has a uniformly poor prognosis [5].
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