Abstract
Background: Systemic lupus erythematosus and lupus nephritis are relatively common autoimmune diseases that can cause damage to multiple systems. Aim: To investigate the lupus activity of patients with lupus nephritis on hemodialysis and the combined occurrence of lupus panniculitis. Case introduction: A patient with lupus nephritis on regular hemodialysis had a symmetrical hard mass under the skin of his abdomen. After surgical resection and pathological examination, she was diagnosed with lupus panniculitis and was treated with glucocorticoids and hydroxychloroquine. After that, no new subcutaneous masses appeared, and the unresectable part of the masses did not increase. Conclusion: 1) Lupus activities in patients with lupus nephritis entering end-stage renal disease still need to be paid attention to. 2) Lupus panniculitis can occur on the skin of the abdomen, and it needs to be differentiated from connective tissue panniculitis, sclerosing panniculitis and other diseases.
Highlights
Systemic lupus erythematosus is a systemic autoimmune disease, which is clinically characterized by recurring lupus activities
1) Lupus activities in patients with lupus nephritis entering end-stage renal disease still need to be paid attention to. 2) Lupus panniculitis can occur on the skin of the abdomen, and it needs to be differentiated from connective tissue panniculitis, sclerosing panniculitis and other diseases
Almost all patients with systemic lupus erythematosus are accompanied by kidney damage [1], and approximately 20% of patients can develop end-stage renal failure within 10 years after the diagnosis of lupus nephritis and require long-term renal replacement therapy
Summary
Systemic lupus erythematosus is a systemic autoimmune disease, which is clinically characterized by recurring lupus activities. It is generally believed that lupus activity will decrease after patients with lupus nephritis enter end-stage renal disease and regularly undergo hemodialysis, but there are still extrarenal manifestations of lupus activity in some dialysis patients. This article aims to further explore the clinical diagnosis, treatment and distinguishing characteristics of lupus panniculitis in hemodialysis patients with lupus nephritis, and to improve the early diagnosis rate of the disease
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