Abstract
Multiple primary malignancies (MPMs) is a rare clinical condition where a patient is diagnosed with two or more cancers around the same time. Published literature reported the incidence of multiple primaries is in the range of 2% - 17%. The risk factors for MPMs are smoking, chronic alcoholism, genetic factors and previous treatment of cancer using radiotherapy that may lead to the development of other cancer. This case report describes a rare and unfortunate case of middle-aged Malaysian Chinese lady diagnosed with adenocarcinoma of the uterus and around the same time she had a recurrent nasopharyngeal carcinoma which was first diagnosed and treated 11 years ago. There were no clear risk factors identified in her and she defaulted follow up which eventually led to a fatal complication in which the nasopharyngeal cancer caused massive bleeding in her and she finally succumbed to the complication despite emergency resuscitations.
Highlights
Multiple primary malignancies (MPMs) are diagnosed when more than one primary malignancy arising in different sites and/or they are of a different histology or morphology group
The actual etiology of MPMs remain unknown but many epidemiological studies have documented MPMs are highly associated with chronic smoking, family history of malignancies, genetic susceptibility, previous exposure to radiation or chemicals and some clinical syndromes such multiple endocrine neoplasm (MEN) 1 and MEN 2 [3] [4]
The following case described a rare and unfortunate case of middle-aged Malaysian Chinese lady who was diagnosed with adenocarcinoma of uterus and around the same time diagnosed with a recurrent nasopharyngeal carcinoma eleven years after the first diagnosis
Summary
Multiple primary malignancies (MPMs) are diagnosed when more than one primary malignancy arising in different sites and/or they are of a different histology or morphology group. This clinical entity is not that common, the worldwide reported frequency of multiple primaries ranges from 2% - 17% [1]. According to International Agency for Research on Cancer, when more than one tumor is confirmed in a patient at the same time or within six-month period. The following case described a rare and unfortunate case of middle-aged Malaysian Chinese lady who was diagnosed with adenocarcinoma of uterus and around the same time diagnosed with a recurrent nasopharyngeal carcinoma (synchronous tumor) eleven years after the first diagnosis
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