Abstract
Adjustment of immunosuppressive and COVID-19 treatment in terms of drug interactions is still challenging. Herein, we report a 45-year-old woman with end-stage renal disease due to autosomal dominant polycystic diseases (ADPKD) with COVID-19 and pulmonary involvement following kidney transplantation. The patient was properly treated by discontinuation of immunosuppressive drugs, bronchoscopy, and high volume of blood transfusions. The fact that we quickly used early intubation and a new treatment regimen that suppressed immune systems may help physicians develop optimal treatment strategies for similar severe cases. However, this treatment method requires more detailed evaluations due to the contradictory results in reviewing other studies.
Highlights
In late December 2019, China officially declared several cases of severe acute respiratory disease in humans, leading to a pandemic by novel coronavirus SARS-CoV-2.1 [1]
The epidemic coronavirus disease rapidly spread worldwide; on 11 March (2020), it was officially stated a pandemic by the World Health Organization (WHO) [2]
It is assumed that RNA beta coronavirus enters the cell and impacted the function of angiotensin-converting enzyme 2 (ACE2) receptors present in the lungs, kidneys, heart, and vascular endothelium [4]
Summary
In late December 2019, China officially declared several cases of severe acute respiratory disease in humans, leading to a pandemic by novel coronavirus SARS-CoV-2.1 [1]. The epidemic coronavirus disease rapidly spread worldwide; on 11 March (2020), it was officially stated a pandemic by the World Health Organization (WHO) [2]. The clinical presentations of infected patients vary from mild symptoms, for instance, flu-like symptoms, including fever, cough, and shortness of breath, to severe and advanced diseases; it was demonstrated that acute respiratory distress syndrome may result in cardiopulmonary collapse [5]. Immunosuppressive therapy in kidney transplant recipients including antilymphocyte therapy, a calcineurin inhibitor (CNI, e.g., tacrolimus), high-dose corticosteroids, and mycophenolate mofetil (MMF) may have influence on health status making patients more susceptible to COVID-19 [7, 8]. We report a case of COVID-19 with pulmonary involvement following kidney transplantation, which was properly treated by discontinuation of immunosuppressive drugs, bronchoscopy, and high volume of blood transfusions
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
