Abstract
The occurrence of more than two ova from the same follicle (polyovular follicle) in humans has been observed. In this case report there was a high frequency of conjoined oocytes retrieved with individual zona pellucida (40% of oocytes retrieved, 4.3% of mature follicles) from women with polycystic ovary syndrome (PCOS). We may have to be more aware of the risk of multiple pregnancies in infertility treatment for PCOS women.
Highlights
IntroductionSince 90 years ago, the occurrence of polynuclear ova and more than two ova from the same follicle (polyovular follicle) in mammals has been reported [1]
Since 90 years ago, the occurrence of polynuclear ova and more than two ova from the same follicle in mammals has been reported [1]
When the dominant follicle reached a diameter of 13 mm, 0.25 mg of daily gonadotropin releasing hormone (GnRH) antagonist (Cetrotide®, Merck Serono Co., Ltd., Tokyo, Japan) subcutaneous injection was started and continued until the day of human chorionic gonadotropin administration
Summary
Since 90 years ago, the occurrence of polynuclear ova and more than two ova from the same follicle (polyovular follicle) in mammals has been reported [1]. The autopsy study shows that tumorlike structure in 29%, binovular follicles in 52% and binuclear oocytes in 19% were identified in pediatric autopsies (pre-term to 15 years old, n=222), but not in adult (20-40 years old, n=22) [5]. It seems that the frequency of binovular follicles could be higher in neonates and prepubertals than in adults in much the same way as in mammals [4, 6,7,8,9]
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