Abstract
BackgroundDiffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently.Case presentationA 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children’s Oncology Group ARST 0331.ConclusionsThis case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.
Highlights
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma
There is an increased than 1% of solid malignancies in adults with around 400 risk of RMS in children with constitutional DICER1 new cases each year in the United States [1, 2]
We report a woman with no significant prior medical history who was diagnosed with simultaneous Embryonal RMS (ERMS) and DLBCL
Summary
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. There is an increased than 1% of solid malignancies in adults with around 400 risk of RMS in children with constitutional DICER1 new cases each year in the United States [1, 2]. Full list of author information is available at the end of the article with alkylating agents and radiation based therapy, these patients are at risk of developing secondary malignancies.
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