Abstract
IntroductionLoperamide is a non-prescription anti-diarrheal agent targeting μ-opioid receptors in the intestinal tract. At high doses it crosses the blood-brain barrier, where μ-opioid agonism can cause euphoric effects. Misuse has been increasing for both the euphoric effects and as an alternative treatment for opioid dependence and withdrawal.Case ReportHere we report the case of a 30-year-old woman presenting with syncope, who was found to have severe myocardial conduction delays in the setting of chronic loperamide abuse.ConclusionTreatment with sodium bicarbonate and hypertonic sodium resulted in improvement of her conduction abnormalities. Prior to discharge she was initiated on buprenorphine for her opioid use disorder.
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