Abstract
Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder. It is characterized by neonatal/ early onset non-autoimmune insulin dependent diabetes (permanent neonatal diabetes mellitus-PNDM) associated with spondyloepiphyseal dysplasia, tendency to skeletal fractures and growth retardation. We report a child with features of WRS, born to consanguineous parents and with an older sister having similar clinical features.
Highlights
Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder
WRS is suggested as the most frequent cause of permanent neonatal diabetes mellitus (PNDM) in children who are born to consanguineous parents.[2,3]
We report a child with features of WRS, born to consanguineous parents and with similar clinical features found in his sister
Summary
Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder. It is characterized by neonatal/early onset nonautoimmune insulin dependent diabetes Associated with spondyloepiphyseal dysplasia, tendency to skeletal fractures and growth retardation.[1]. WRS is suggested as the most frequent cause of PNDM in children who are born to consanguineous parents.[2,3]. We report a child with features of WRS, born to consanguineous parents and with similar clinical features found in his sister
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